Cuscuta reflexa Roxb. (Fam. Convolvulaceae) is commonly known as aftimoon, amarbel, akashbel, or dodder in the alternative medicine system. It is widely used in the Unani system of medicine (USM) for its useful therapeutic effects due to its active constituents. It is used to cure various diseases through anti-tumor activity, anti-arthritis, hypotensive and bradycardia effects. Various phytoconstituents were isolated from it, like protein, alkaloids, flavonoids, dulcitol, luteolin, quercetin. The kaempferol and quercetin, a major active constituent in it, have various therapeutic activities apart from antidiabetic activity. In USM, Cuscuta reflexa is used to treat hepatitis, melancholia, chronic splenitis, and cancer. Many pharmacological studies have been carried out to explore its hypotensive, anti-HIV, antibacterial, antioxidant activities. This review will provide a comprehensive overview of Cuscuta reflexa with special reference to Unani medicine and validate its various effects by pharmacological studies done so far.